Founded in 1984 as the Department of Applied Microbiology alongside the inception of the Department of Biochemistry, the Department of Microbiology has traversed a dynamic history marked by administrative changes. Initially named the Department of Applied Microbiology, it later underwent a merger in 1987, amalgamating with the Botany department and was designated as the Department of Botany and Applied Microbiology. This administrative shift was prompted by the limited availability of senior staff at that time. However, in a significant development, the Department reclaimed its autonomous status in October 1989, reinforcing its distinct identity within the academic landscape.

During the late 80s, the Department boasted a roster of esteemed academic staff, including Prof. S. K. Ogundana, Dr. M. A. Faluyi, Dr. J. A. Akinyanju, Dr. O. A. Akande, and others. These pioneers laid the foundation for the academic excellence and growth that the Department would later experience.

In its nascent years, the Department relied on the expertise of Mr. Falana S. O., who served as the solitary technologist until 1992. The subsequent inclusion of Mrs. S. O. Fasuan marked a pivotal moment in expanding the technical support team. Other key members included Mr. Ajayi, S. S., Mrs. Adeosun, O. M., Mr. Ibrahim O., Mrs. Ejonona, I. T., Mr. Adesuyi A. S., and Mr. Adebayo A. A., who collectively contributed to the efficient functioning of the laboratory.

The laboratory, equipped with relevant instruments, housed essential equipment such as the Genlab incubator, Binocular microscopes, Water bath, Electrophoresis units, and a Precision balance (Ohaus). The inclusion of these tools facilitated a conducive environment for research and practical training, ensuring that students were exposed to contemporary laboratory practices.

Presently, the Department stands as a testament to its journey of growth and evolution. With a current roster of academic staff that includes Prof. (Mrs.) E.Y. Aderibigbe, Prof. J. O. Oluyege, Prof. (Mrs.) T. O. Femi-Ola, Professor C. R. Falegan, Prof. (Mrs) A. O. Oluyege, Prof. D. E. Fagbohun, Prof. O. M. David, Dr. (Mrs.) T. R. Omodara, and Dr. (Mrs.) T. O. Olowomofe. The department continues to provide quality education and the focus areas of training have expanded to include Food and Industrial Microbiology, Environmental Microbiology, and Medical and Pathogenic Microbiology. The department has experienced significant strides in terms of student enrollment, and the current acting Head of Department is Prof. C. R. Falegan. The narrative of the Department of Microbiology reflects not only its storied past but also its enduring commitment to academic excellence and the advancement of microbiological knowledge.